Status Diverges Muscle Diacylglycerol Accumulation During Free Fatty Acid
نویسندگان
چکیده
Training Status Diverges Muscle Diacylglycerol Accumulation During Free Fatty Acid 2 Elevation 3 4 Short title: Training Effects on Muscle Lipid During FFA Elevation 5 6 7 Lisa S Chow1 8 Douglas G. Mashek2 9 Erin Austin 3 10 Lynn E. Eberly 3 11 Xuan-Mai Persson 12 Mara T. Mashek 2 13 Elizabeth R. Seaquist 1 14 Michael D. Jensen 15 16 1 Department of Medicine, University of Minnesota, Minneapolis MN , Department of Food 17 Science and Nutrition, University of Minnesota, Minneapolis MN, Division of Biostatistics, 18 University of Minnesota, Minneapolis MN, Department of Medicine, Mayo Clinic College of 19 Medicine, Rochester MN 20 21 Corresponding author: 22 Lisa S Chow MD, MS 23 MMC 101 24 420 Delaware St SE 25 Minneapolis, MN 55455 26 612-625-8934 27 Fax 612-626-3133 28 Email: [email protected] 29 30 31 Author contributions: 32 LSC and ES designed the research. LSC, DM, XMP, MM, MJ provided essential data for 33 analysis. LSC, EA, LE analyzed the data. LSC, EA, LEE, XMP wrote the manuscript. LSC, 34 DM, EA, LE, XMP, MM, ES, MJ contributed to the discussion and reviewed/edited the 35 manuscript. LSC has primary responsibility for the final content. All authors have read and 36 approved the final manuscript. 37 38 39 Disclosure: 40 No conflict of interest to report 41 42 43 Articles in PresS. Am J Physiol Endocrinol Metab (May 20, 2014). doi:10.1152/ajpendo.00166.2014
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Training status diverges muscle diacylglycerol accumulation during free fatty acid elevation.
How endurance training alters muscle lipid metabolism while preserving insulin sensitivity remains unclear. Because acute free fatty acid (FFA) elevation by lipid infusion reduces insulin sensitivity, we hypothesized that training status would alter accumulation of muscle triacylglycerol (TAG), diacylglycerol (DAG), ceramide, and acylcarnitine during acute FFA elevation. Trained (n = 15) and se...
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